
Mississippi River Cruises
From the bayous to the bluffs of Minnesota, on paddlewheelers and modern riverboats.
Get Free US River Cruise QuotesThe Mississippi is America’s best-known river cruise, and for good reason. It runs from the Minnesota woods to the Gulf of Mexico, and a small ship lets you stop at the towns that grew up along it — places with antebellum mansions, Civil War battlefields, blues clubs and riverfront main streets.
Lower Mississippi: New Orleans to Memphis
The southern river is wide, brown and slow, lined with levees and old river towns. Typical stops include Baton Rouge, St. Francisville, Natchez, Vicksburg and Greenville before Memphis. Expect plantation-era history told with more honesty than it used to be, the Vicksburg battlefield, Delta blues and very good food. Many itineraries start or end with a hotel night in New Orleans.
Upper Mississippi: St. Louis to St. Paul
North of St. Louis the river narrows and climbs through a series of locks and dams, past bluffs and small towns such as Hannibal, Mark Twain’s boyhood home, and river towns in Iowa, Wisconsin and Minnesota. Late September and October bring fall color, and those sailings are popular.
Who Sails the Mississippi
- American Cruise Lines runs the most departures, on modern riverboats and paddlewheelers, with Lower and Upper Mississippi cruises, full-river voyages, and tributary trips. For 2026 it added an Arkansas River cruise from Memphis to Tulsa and a Gulf Coast itinerary that includes part of the Lower Mississippi.
- Viking sails the Viking Mississippi, a 386-guest ship with 193 outside staterooms. Its itineraries include Mississippi Delta Explorer (New Orleans–Memphis), Heartland of America (St. Louis–St. Paul) and New Orleans & Southern Charms, and for 2027 Viking announced new voyages that continue up the Ohio River to Louisville.
Both lines are adults-oriented; Viking does not accept guests under 18.

When to Go
| Season | Lower Mississippi | Upper Mississippi |
|---|---|---|
| Spring | Pleasant; azaleas and gardens | Cool; season starting |
| Summer | Hot and humid | Warm; good for long one-way voyages |
| Fall | Comfortable again | Peak fall color, very popular |
| Winter | Some sailings around New Orleans | River towns quiet; limited sailings |
A Day on the Lower Mississippi
Mornings often begin with the ship tied up below a levee, a short shuttle from the town. In Natchez you might tour antebellum homes on the bluff; in Vicksburg, drive the battlefield park with a guide; in St. Francisville, walk under live oaks to a plantation-era house. Afternoons bring long stretches of river with barges, herons and wide skies, and evenings on many ships feature live music — jazz, blues or a riverboat singalong. Cajun and Creole flavors show up on the menu more and more as you head south.
Frequently Asked Questions
Upper or Lower Mississippi for a first trip?
The Lower Mississippi, between New Orleans and Memphis, is the classic: plantation-era history, Civil War sites, Southern food and the blues. The Upper Mississippi, between St. Louis and St. Paul, is quieter, greener and famous for fall color and locks.
Are there locks on the Mississippi?
Not on the Lower Mississippi. Above St. Louis, the Upper Mississippi is a staircase of locks and dams, and your ship will pass through several on a typical cruise.
Can I sail the whole river?
Yes. Both American Cruise Lines and Viking offer long one-way voyages between New Orleans and the Twin Cities on selected dates.
Get Quotes for the Mississippi
Tell us your month, how many are traveling and the ship size you prefer. Our cruise advisors at Mister Cruise will compare the lines sailing the Mississippi and send free quotes.
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